Masoud Zamani Esteki

Masoud Zamani Esteki, PhD

Assistant professor

Focus areas

Reproductive Genetics
Single-cell Genomics
Genomic Medicine


Contact

Masoud Zamani Esteki, PhD
Maastricht UMC+
Clinical Genetics
PO Box 5800
6202 AZ Maastricht
T: +31 (0)43 3875306
T: +31 (0)43 3871273  / 3871272 (secretary)
E: masoud.zamaniesteki@mumc.nl / m.zamaniesteki@maastrichtuniversity.nl 
W: www.zamanilab.org

Curriculum vitae

Masoud Zamani Esteki is an early-career scientist with a general interest in development and application of innovative methods for deciphering different molecular layers, their connectivity and their impact on cellular identity and function. He constantly explores new avenues towards translating his research into the clinic.

During the course of his doctoral and postdoctoral research, Masoud has developed methods to study genome (in)stability in early human development with application to the clinic, e.g. preimplantation genetic testing (PGT). Specifically, he has employed the acquired knowledge during his BSc., MSc. and Advanced Master programs, such that his research work was an intersection of classical genetics, molecular and developmental genetics, clinical genetics, bioinformatics and artificial intelligence. He has been developing, applying and translating wet- and dry-lab approaches that uncover the genome’s allelic architecture and its relation to other molecular layers in samples derived from many cells down to a single cell.

Timeline

  • 2017 - present: Assistant professor, Maastricht UMC+, the Netherlands
  • 2015 - 2017: Postdoctoral scientist / Research associate, KU Leuven, Belgium
  • 2011 - 2015: PhD in Molecular and Developmental Genetics, KU Leuven, Belgium
  • 2009 - 2010: Advanced Master in Artificial Intelligence, Engineering and Computer Science, KU Leuven, Belgium
  • 2007 - 2009: Master of Science in Bioinformatics, KU Leuven, Belgium
  • 2003 - 2007: Bachelor of Science in Molecular Cell Biology, Genetics, Shahid Chamran University of Ahvaz, Iran

Honors

2019: Finalist for the Joe Leigh Simpson Award for the Best Early Career Investigator, International Society of Prenatal Diagnosis and Therapy (ISPD)
2015: Trainee Paper Spotlight for outstanding publication and research done by trainee members of ASHG
2015: Winner of the International Royan Award for outstanding research in Reproductive Genetics, Tehran, Iran
2014: Winner of Charles J. Epstein Trainee Award for Excellence in Human Genetics Research, San Diego, USA
2014: Awarded for the best oral presentation in basic research at PGDIS 2014, Kent, UK
2014: Candidate for the Young Investigator Awards of the ESHG 2014 Conference, Milan, Italy
2012: Nominated for the Royan International award, Tehran, Iran
2012: Travel grant for the Royan International Twin Congress, Tehran, Iran
2011: Winner of the ESHG fellowship for 4th Course in Integration of cytogenetics, microarray and massive sequencing in biomedical and clinical research, Bologna, Italy

People involved

Prof. Han Brunner (faculty mentor); Alexander Hoischen, PhD (lead NGS technologies); Christian Gilissen, PhD (lead bioinformatics); prof. Christine de Die-Smulders (PGD professor); Aimée Paulussen, PhD (lab specialist, PGD); ing. Joseph Dreesen (chief technical PGD); Servi Stevens, PhD (lab specialist, NIPT); Merryn Macville, PhD (lab specialist, NIPT); Edith Coonen, PhD (clinical embryologist); Aafke van Montfoort, PhD (clinical embryologist); Nicolas Rivron, PhD (stem-cell biologist); Marij Gielen, PhD (epidemiologist); Kasper Derks, PhD (bioinformatician); Bart de Koning, PhD (bioinformatician); Jeroen Meekels (PhD student)

Team Cellular Genomic Medicine

Jeroen Meekels (PhD student), Rebekka Koeck (PhD student), Gaby Schobers (postgraduate student), Britt Thomassen (undergraduate student)

Alumni

Jesko Wagner (undergraduate student)

Patents

  • Zamani Esteki, M., Vermeesh, J.R., Voet, T. (2015) Haplotyping and copy number typing by polymorphic variant allele frequencies. ZL913096 - PCT/EP2014/068315 - WO/2015/028576
  • Vermeesh, J.R., Voet, T., Zamani Esteki, M.  (2011) Methods for haplotyping single cells. ZL910050 -PCT/EP2011/060211 - WO/2011/157846

Teaching

Selected publications

Masoud Zamani Esteki, Triin Viltrop, Olga Tšuiko, Airi Tiirats, Mariann Koel, Margit Nõukas, Olga Žilina, Katre Teearu, Heidi Marjonen, Hanna Kahila, Jeroen Meekels, Viveca Söderström-Anttila, Anne-Maria Suikkari, Aila Tiitinen, Reedik Mägi, Sulev Kõks, Nina Kaminen-Ahola, Ants Kurg, Thierry Voet, Joris Robert Vermeesch & Andres Salumets. In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages, Nature Medicine, November 2019. See also the video

Zamani Esteki, M.#*, Ardeshirdavani, A*, Alcaida, D.*, Masset, H.*, Ding, J.*, Sifrim, A., Kumar, P., Dimitriadou, E., Aerts, J. , Voet, T.#, Moreau, Y.#, Vermeesch, J#. HiVA: an integrative wet- and dry-lab platform for haplotype and copy number analysis of single-cell genomes. *Co-first author, #Co-senior/corresponding author (preprint: https://doi.org/10.1101/564914).

Masset H.*, Zamani Esteki, M.*, Dimitriadou E., Dreesen J., Debrock S., Derhaag J., Derks K., Destouni A., Drusedau M., Meekels J., Melotte C., Peeraer K., Tsuiko O., Van Uum C., Allemeersch J., Devogelaere B., François K., Happe S., Lorson D., Richards RL., Theuns J., Brunner H., De Die-Smulders C., Voet T., Paulussen A., Coonen E., Vermeesch J. (2019). Multi-centre evaluation of a comprehensive preimplantation genetic test through haplotyping-by-sequencing. Human reproduction doi: 10.1093/humrep/dez106. [Epub ahead of print] *Co-first author.

Zamani Esteki, M., Dimitriadou, E., Mateiu, L., Melotte, C., Jackmaert, S., Van der Aa, N., Kumar, P., Das, R., Theunis, K., Cheng, J., Brems, H., Legius E., Moreau, Y., Debrock, S., D'Hooghe, T., Verdyk, P., De Rycke, Sermon, K., Vermeesch, J., Voet, T. Concurrent haplotyping and copy-number profiling of single cells. (2015). The American Journal of Human Genetics, 96 (6), art.nr. S0002-9297(15)00148-2, 894-912.

*Destouni, A., *Zamani Esteki, M., Catteeuw, M., Tsuiko, O., Dimitriadou, E., Kurg, A., Salumets, A., Van Soom A., Voet, T., Vermeesch, J.  (2016). Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage stage chimaerism and mixolpoidy. Genome research, 26 (5), art.nr. 10.1101/gr.200527.115, 567-78.
* These authors are joint first-authors and contributed equally to this work.

*Tsuiko, O., *Catteeuw, M., *Zamani Esteki, M., Destouni, A., Bogado Pascottini, O., Besenfelder, U., Havlicek, V., Smits, K., Kurg, A., Salumets, A., Voet, T., Van Soom, A., Vermeessch, J.R., (2017). Genome stability of in vivo-conceived cleavage-stage embryos is higher compared to in vitro produced embryos. Human reproduction, 32(11), art.nr. 10.1093/humrep/dex286, 2348-2357.
* These authors contributed equally to this work.

Voet, T., Kumar, P., Van Loo, P., Cooke, S., Marshall, J., Lin, M., Zamani Esteki, M., Van der Aa, N., Mateiu, L., McBride, D., Bignell, G., McLaren, S., Teague, J., Butler, A., Raine, K., Stebbings, L., Quail, M., D'Hooghe, T., Moreau, Y., Futreal, P., Stratton, M., Vermeesch, J., Campbell, P. (2013). Single-cell paired-end genome sequencing reveals structural variation per cell cycle. Nucleic acids research, 41 (12), 6119-6138.

Robberecht, C., Voet, T., Zamani Esteki, M., Nowakowska, B., Vermeesch, J. (2013). Non-allelic homologous recombination between retrotransposable elements is a driver of de novo unbalanced translocations. Genome research, 23 (3), 411-418.

Overview

A detailed list of Masoud’s publications, conference presentations and proceedings can be found at:

ORCiD
ResearchGate

 

 

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