Public health genomics, type 2 diabetes (T2DM), rare diseases
Henk van Kranen, PhD
PO Box 616
6200 MD Maastricht
National Institute for Public Health & Environment (RIVM)
Center for Nutrition, Prevention and Health Services
T: (+31) (0)30 2743573
M: (+31) (0)6 22550079
Henk van Kranen, PhD was trained as a molecular biologist at Leiden University (prof. Van der Eb) and earned his PhD at the Medical Faculty of Utrecht University (prof. J.L. Bos) with a thesis entitled ‘Genetic alterations in chemically induced gastro-intestinal tumors and UVB-induced skin tumors of rodents’. In particular causality of anti-carcinogenic compounds as suggested from epidemiological studies, was tested in a variety of chemically induced as well as genetically modified murine models. He has published around 70 articles in peer-reviewed journals.
In the postdoctoral years, amongst others, he expanded his activities in cancer research from experimental animal work to genetic epidemiology and contributed to WCRF’s 2007 report as a cancer biologist. More recently he became involved as an editor and advisor in genomics, with special emphasis on nutrigenomics and public health genomics.
Henk van Kranen is trying to contribute to the further connection of public health genomics research towards RIVM mediated health policy support for the Ministry of Public Health, Welfare and Sport. At present two topics are explored.
Contributing to policy reports for ZonMw (Van de Berg & Van Kranen, RIVM report 270524001/2013, Public health genomics: 'Wat zijn de kansen voor preventie?') and RIVM’s Public Health Forecasting report 2014 in preparation.
Investigate whether genomics knowledge of type 2 diabetes (T2DM) about susceptibility and interactions with drugs and food may contribute to a more personalized approach of prevention and treatment of T2DM as part of a research progam of TNO called P4 diabetes clinic.
Try to connect the international networking power of IPHG (Angela Brand) on Rare Disesases with strategic future plans at RIVM to coordinate information in this field. More specific, how to connect present basic information and forthcoming diagnostic data from NGS platforms at clinical genetics centers with maximum support of international/European activities and networks.
Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice. Grimaldi, K.A., van Ommen, B., Ordovas, J.M., Parnell, L.D., Mathers, J.C., Bendik, I., Brennan, L., Celis-Morales, C., Cirillo, E., Daniel, H., de Kok, B., El-Sohemy, A., Fairweather-Tait, S.J., Fallaize, R., Fenech, M., Ferguson, L.R., Gibney, E.R., Gibney, M., Gjelstad, I.M.F., Kaput, J. & 16 others Karlsen, A.S., Kolossa, S., Lovegrove, J., Macready, A.L., Marsaux, C.F.M., Martinez, J.A., Milagro, F., Navas-Carretero, S., Roche, H.M., Saris, W.H.M., Traczyk, I., van Kranen, H., Verschuren, L., Virgili, F., Weber, P. & Bouwman, J. 15 Dec 2017. Genes and nutrition, 12, 12 p., 35.
Policy Making in Newborn Screening Needs a Structured and Transparent Approach. Jansen, M. E., Lister, K. J., van Kranen, H. J. & Cornel, M. C. 21 Mar 2017. Frontiers in Public Health. 5, 6 p., 53.
Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance. Brouwer-Brolsma, E.M., Brennan, L., Drevon, C.A., van Kranen, H., Manach, C., Dragsted, L.O., Roche, H.M., Andres-Lacueva, C., Bakker, S.J.L., Bouwman, J., Capozzi, F., De Saeger, S., Gundersen, T.E., Kolehmainen, M., Kulling, S.E., Landberg, R., Linseisen, J., Mattivi, F., Mensink, R.P., Scaccini, C. & 6 others Skurk, T., Tetens, I., Vergeres, G., Wishart, D.S., Scalbert, A. & Feskens, E.J.M. Nov 2017. Proceedings of the Nutrition Society. 76, 4, p. 619-627 9 p.
UV-straling en gezondheid: Probleemveld en kennisbasis bij het RIVM. Slaper, H., van Dijk, A., den Outer, P. N., van Kranen, H. & Slobbe, L. Jun 2017 RIVM. 77 p.
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. Van Duijnhoven FJB, Jenab M, Hveem K, Siersema PD, Fedirko V, Duell EJ, Kampman E, Halfweeg A, van Kranen HJ, van den Ouweland JMW, Weiderpass E, Murphy N, Langhammer A, Ness-Jensen E, Olsen A, Tjønneland A, Overvad K, Cadeau C, Kvaskoff M, Boutron-Ruault MC, Katzke VA, Kühn T, Boeing H, Trichopoulou A, Kotanidou A, Kritikou M, Palli D, Agnoli C, Tumino R, Panico S, Matullo G, Peeters P, Brustad M, Olsen KS, Lasheras C, Obón-Santacana M, Sánchez MJ, Dorronsoro M, Chirlaque MD, Barricarte A, Manjer J, Almquist M, Renström F, Ye W, Wareham N, Khaw KT, Bradbury KE, Freisling H, Aune D, Norat T, Riboli E, Bueno-de-Mesquita HBA.. Int J Cancer. 2018 Mar 15;142(6):1189-1201