Complex Genetics

Applied Epidemiology and Meta-Research

The purpose of Epidemiology, and of any research for that matter, is to use the knowledge that we generate. What, if anything, is more important than that? We suffer and struggle, but thrive—until we discover new knowledge that can be translated to society, and then we start again. This team focusses specifically on the Application of Epidemiologic Research to governance, the Legal Court, the market and to the Research Process itself.

Epidemiology 2 Governance

  • Risk-based supervision of healthcare (IGZ)

Epidemiology 2 Market

  • Time trends in the incidences of human health disorders hypothesised to be associated with exposure to endocrine disrupting chemicals (ECPA)
  • A systematic review of phthalate epidemiology studies (ECPI)
  • Medical Analytics Consultancy (MEDICALANALYTICS)
  • Live a longer, healthier and happier life (Health Potential)
  • Fit4Life (Sport Potential)

Epidemiology 2 Court

The discipline of forensic epidemiology (FE) is a hybrid of principles and practices common to both forensic medicine and epidemiology. FE is directed at filling the gap between clinical judgment and epidemiological data for determinations of causality in civil lawsuits and criminal prosecution and defence. Forensic epidemiologists formulate evidence-based probabilistic conclusions about the type and quantity of causal association between an antecedent harmful exposure and an injury or disease outcome in both populations and individuals. The conclusions resulting from an FE analysis can support legal decision-making regarding guilt or innocence in criminal actions, and provide an evidentiary support for findings of causal association in civil actions. Applications of forensic epidemiologic principles are found in a wide variety of types of civil litigation, including cases of medical negligence, toxic or mass tort, pharmaceutical adverse events, medical device and consumer product failures, traffic crash-related injury and death, person identification and life expectancy. Please see: Forensic Epidemiology.

Epidemiology 2 The Research Process

  • Selective citation in science based decision-making (SOUNDSCIENCE)
  • Determinants of protocol provision, quality and concordance in observational research (ECPI)
  • European Ethics and Research Integrity Network (ENERI)
  • Responsible Epidemiologic Research Practice (RERP)

Team leader

Prof. Maurice Zeegers

Last 10 publications

  1. Swaen GM, Urlings MJ, Zeegers MP. Outcome reporting bias in observational epidemiology studies on phthalates. Ann Epidemiol 2016; 26(8): 597-9 e4
  2. Sobczak F, Burdorf A, Zeegers MP. Law and epidemiology: Misinterpretation of epidemiologic information in claims for asbestos-related diseases. OA Epidemiology 2014; 2(1): 1
  3. Freeman MD, Goodyear S, Leith W. Risk factors for neonatal brachial plexus injury; a multistate epidemiologic study of matched maternal and newborn discharge records. Int J Gynecology & Obstetrics (in press)
  4. Zeegers M, Bours M, Freeman M. Methods used in forensic epidemiological analysis. In: Zeegers M, Freeman M, eds. Forensic Epidemiology: principles and practices London: Elsevier; 2016
  5. Siegerink B, den Hollander W, Zeegers M, Middelburg R. Causal Inference in Law: An Epidemiological Perspective. European journal of Risk Regulation 2016; 1: 175-86
  6. Faure M, Visscher L, Zeegers M, Freeman M. The role of the expert witness. In: Zeegers M, Freeman M, eds. Forensic Epidemiology: principles and practices London: Elsevier; 2016
  7. Freeman MD, Zeegers MP. Principles and applications of forensic epidemiology in the medicolegal setting. Law Probability and Risk 2015; 14(4): 269-78van Osch FH, Jochems SH, van Schooten FJ, Bryan RT, Zeegers MP. Quantified relations between exposure to tobacco smoking and bladder cancer risk: a meta-analysis of 89 observational studies. Int J Epidemiol 2016
  8. Al-Zalabani AH, Stewart KF, Wesselius A, Schols AM, Zeegers MP. Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses. Eur J Epidemiol 2016
  9. van Osch FH, Jochems SH, van Schooten FJ, Bryan RT, Zeegers MP. Significant role for lifetime cigarette smoking in worsening bladder cancer and upper tract urothelial carcinoma prognosis: a meta-analysis. The Journal of Urology 2015
  10. Joris PJ, Zeegers MP, Mensink RP. Weight loss improves fasting flow-mediated vasodilation in adults: a meta-analysis of intervention studies. Atherosclerosis 2015; 239(1): 21-30